Derivation of Trisomy 21 affected human embryonic stem cell line Genea021
نویسندگان
چکیده
منابع مشابه
Derivation of human embryonic stem cell lines.
Human embryonic stem cells (hESC) are undifferentiated cells derived from an early embryo that can grow in vitro indefinitely, while retaining their capability to differentiate into specialized somatic cell types. Over the last decade there has been great interest in derivation and culture of these cells, as they can potentially provide a supply of readily available differentiated cells and tis...
متن کاملEstablishment of human-embryonic-stem-cell line from mosaic trisomy 9 embryo.
OBJECTIVE Human-embryonic-stem-cell (hESC) lines derived from chromosomally or genetically abnormal embryos obtained following preimplantation genetic diagnosis are valuable in investigating genetic disorders. MATERIALS AND METHODS In this study, a new hESC line, Center of Clinical Reproductive Medicine 8 (CCRM8) was established by isolation, culture, and passaging of the inner cell mass of m...
متن کاملDerivation of embryonic stem-cell lines from human blastocysts.
Embryonic stem cells have the unique ability to form all adult cell types. Harnessing this potential may provide a source of cells to replace those that are lost or impaired as a result of disease. Moreover, the derivation of human embryonic stem cells opens a unique window into the study of early human development. At present, approximately 15 human embryonic stem-cell lines are publicly avail...
متن کاملDerivation of the human embryonic stem cell line RCe008-A (RC-4).
The human embryonic stem cell line RCe008-A (RC-4) was derived from a blastocyst voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to ectoderm and mesoderm in vitro. It has...
متن کاملDerivation of the human embryonic stem cell line RCe014-A (RC-10).
The human embryonic stem cell line RCe014-A (RC-10) was derived from a fresh oocyte voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It ...
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ژورنال
عنوان ژورنال: Stem Cell Research
سال: 2016
ISSN: 1873-5061
DOI: 10.1016/j.scr.2016.02.010